You should not use this medicine if you are allergic to metformin or pioglitazone, or if you have:
- 严重的心力衰竭；
- 严重的肾脏疾病；
- active bladder cancer; or
- metabolic acidosis or ketoacidosis (call your doctor for treatment).
如果您需要使用注入静脉的染料进行手术或任何类型的X射线或CT扫描，则可能需要暂时停止服用二甲双胍和吡格列酮。Be sure your caregivers know ahead of time that you are using this medicine.
Tell your doctor if you have ever had:
- 肾脏问题；
- congestive heart failure or other heart problems;
- fluid retention;
- 糖尿病引起的眼睛问题；
- 膀胱癌;
- 心脏病发作或中风；
- 肝病;或者
- 如果您年满80岁。
This medication may increase your risk of developing bladder cancer. Talk with your doctor about your specific risk.
You may developlactic acidosis,a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.
二甲双胍和吡格列酮may increase your risk of serious heart problems,但是，不治疗糖尿病也会损害您的心脏和其他器官。与您的医生谈谈这种药物的风险和好处。
遵循您的医生有关使用此药物的指示if you are pregnant or you become pregnant.在怀孕期间，控制糖尿病非常重要，血糖含量可能会导致母亲和婴儿的并发症。
二甲双胍可能会刺激绝经前女性排卵，并可能增加意外怀孕的风险。与您的医生谈谈您的风险。
Women may be more likely to have a broken bone while using metformin and pioglitazone. Talk with your doctor about ways to keep your bones healthy.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
二甲双胍和吡格列酮未获得18岁以下的任何人使用。
