Cobicistat (Tybost)
Cobicistat is given together with atazanavir (Reyataz) or darunavir (Prezista) to treat human immunodeficiency virus (HIV), the virus that can cause acquired immunodeficiency syndrome (AIDS).
Cobicistat is used to increase your blood levels of these medicines, helping to make them safer and more effective at lower doses.
Cobicistat is not an antiviral medicine and will not treat HIV or AIDS.Cobicistat is given only to help increase your blood levels of atazanavir or darunavir.
When given with atazanavir,cobicistat is for use in adults and children weighing at least 77 pounds (35 kilograms).When given with darunavir,cobicistat is for use in adults and children weighing at least 88 pounds (40 kilograms).
Cobicistat may also be used for purposes not listed in this medication guide.
uses
What isCobicistat (Tybost)used for?
- HIV Infection
warnings
What is the most important information I should know aboutCobicistat (Tybost)?
Cobicistat is not a complete treatment and must be used in combination only with atazanavir or darunavir.You should not take cobicistat with any other antiviral medicines that your doctor has not prescribed.
You should not take cobicistat if you are allergic to it.
Many drugs can interact and cause dangerous effects that could lead to death.Some drugs should not be used together.
You should not take cobicistatwith atazanavirif you also take:
- indinavir;
- irinotecan;
- nevirapine; or
- birth control pills that contain drospirenone and ethinyl estradiol (Beyaz, Sayfral, Yasmin, Yaz).
You should not take cobicistatwith atazanavir or darunavirif you also take:
- alfuzosin;
- cisapride;
- colchicine;
- dronedarone;
- oral midazolam, or triazolam;
- ranolazine;
- rifampin;
- sildenafil (Revatio, for treating pulmonary arterial hypertension);
- St. John's wort;
- antipsychotic medicine--lurasidone, pimozide;
- cholesterol medication--lomitapide, lovastatin, simvastatin;
- ergot medicine--dihydroergotamine, ergotamine, methylergonovine; or
- seizure medication--carbamazepine, phenobarbital, phenytoin.
You may not be able to take cobicistat if you also take:
- darunavir 600 milligrams twice daily; or
- certain other antiviral medicines--fosamprenavir, saquinavir, or tipranavir.
Tell your doctor if you have ever had:
- liver disease; or
- kidney disease, especially if you also take tenofovir.
Cobicistat may not work as well if you take it during pregnancy.不服用药物吗f you are pregnant. Tell your doctor right away if you become pregnant.
If you plan to get pregnant,ask your doctor for another antiviral medicine to use during pregnancy. Use all medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.
If you do not plan to get pregnant,ask your doctor about using a non-hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy. Cobicistat can increase certain side effects when taken with hormonal birth control (pills, injections, implants, skin patches, vaginal rings).
Women with HIV or AIDS should not breastfeed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.
Side Effects
What are the side effects ofCobicistat (Tybost)?
Get emergency medical help if you havesigns of an allergic reaction:hives; difficult breathing; swelling of your face, lips, tongue, or throat.
马上打电话给你的医生如果你有:
- kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or
- liver problems--upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Common side effects may include:
- nausea;
- jaundice; or
- rash.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I takeCobicistat (Tybost)if I’m pregnant or breastfeeding?
Cobicistat may not work as well if you take it during pregnancy.不服用药物吗f you are pregnant. Tell your doctor right away if you become pregnant.
If you plan to get pregnant,ask your doctor for another antiviral medicine to use during pregnancy. Use all medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.
If you do not plan to get pregnant,ask your doctor about using a non-hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy. Cobicistat can increase certain side effects when taken with hormonal birth control (pills, injections, implants, skin patches, vaginal rings).
Women with HIV or AIDS should not breastfeed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.
Interactions
What drugs and food should I avoid while takingCobicistat (Tybost)?
Using this medicine will not prevent your disease from spreading.Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.
Dosage Guidelines & Tips
How to takeCobicistat (Tybost)?
UseCobicistat (Tybost)exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Cobicistat is usually taken once per day with atazanavir or darunavir.
Take your HIV medicines with food at the same time each day to be sure you do not miss a dose.
If you take cobicistat with atazanavirand you also take medicine to reduce stomach acid, follow these recommendations unless your doctor tells you otherwise:
- If you take an antacid, take it at least 2 hours before or 2 hours after you take cobicistat and atazanavir.
- If you take a medicine such as cimetidine, ranitidine, Tagamet, Axid, Zantac, Pepcid, and others: Take the stomach medicine at the same time you take cobicistat and atazanavir; or wait at least 10 hours after taking the stomach medicine to take your cobicistat and atazanavir doses.
- If you take a proton pump inhibitor such as omeprazole, esomeprazole, Nexium, Prevacid, Prilosec, Protonix: Wait at least 12 hours after taking the stomach medicine to take your cobicistat and atazanavir doses.
You will need frequent medical tests.
Use all HIV medications as directed and read all medication guides you receive.Do not change your dose or dosing schedule without your doctor's advice.Every person with HIV should remain under the care of a doctor.
Store in the original container at room temperature, away from moisture and heat. Keep the bottle tightly closed when not in use.
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose.Do nottake two doses at one time.
Get your prescription refilled before you run out of medicine completely.
Overdose Signs
What happens if I overdose onCobicistat (Tybost)?
Images
GSI
Color: orange
Shape:圆
Form: film coated
Imprint: GSI