Jentadueto（Linagliptin和二甲双胍）

Linagliptin和二甲双胍是有助于控制血糖水平的口服糖尿病药物。二甲双胍通过减少肝脏中的葡萄糖（糖）产生并减少肠道吸收。Linagliptin通过调节进食后身体产生的胰岛素水平来起作用。

Linagliptin and metformin is a combination medicine used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.This medicine is not for treating type 1 diabetes.

Linagliptin和二甲双胍也可以用于本药物指南中未列出的目的。

warnings

什么是the most important information I should know aboutJentadueto（Linagliptin和二甲双胍）？

如果您对Linagliptin（Tradjenta）或二甲双胍过敏，或者如果您患有严重的肾脏疾病或糖尿病性酮症酸中毒（致电医生接受胰岛素治疗），则不应使用这种药物。

Tell your doctor if you have ever had:

肾脏疾病;
心脏病;
肝病;
pancreatitis;
gallstones;
酗酒;或者
高甘油三酸酯（血液中的一种脂肪）。

您可能会发展lactic acidosis,a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.

如果您需要使用注射到静脉中的染料进行手术或任何类型的X射线或CT扫描，则可能需要暂时停止服用Linagliptin和二甲双胍。确保您的护理人员提前知道您正在使用这种药物。

告诉医生您是否怀孕或母乳喂养。

遵循您的医生有关使用此药物的指示if you are pregnant or you become pregnant.在怀孕期间，控制糖尿病非常重要，血糖含量可能会导致母亲和婴儿的并发症。

这种药物可能会刺激绝经前女性排卵，并可能增加意外怀孕的风险。与您的医生谈谈您的风险。

This medicine is not approved for use by anyone younger than 18 years old.

副作用

What are the side effects ofJentadueto（Linagliptin和二甲双胍）？

Get emergency medical help if you have过敏反应的迹象（蜂箱，呼吸困难，脸部或喉咙肿胀）或者a severe skin reaction(fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Stop taking this medicine and call your doctor right away if you havesymptoms of pancreatitis：上胃的剧烈疼痛蔓延到您的背部，恶心和呕吐，食欲不振或快速心跳。

随着时间的流逝，乳酸酸中毒的轻度症状可能会恶化, and this condition can be fatal. Get emergency medical help if you have: unusual muscle pain, trouble breathing, stomach pain, vomiting, fast/slow or irregular heartbeats, dizziness, feeling cold, or feeling very weak or tired.

如果有的话，请立即致电医生：

严重的自身免疫反应- 迹，水泡，皮肤外层的崩溃；
severe or ongoing pain in your joints; or
symptoms of heart failure--shortness of breath (even while lying down), swelling in your legs or feet, rapid weight gain.

Common side effects may include:

sore throat;
鼻窦疼痛，鼻塞；或者
腹泻。

这不是副作用的完整列表，其他可能发生。打电话给您的医生，征求有关副作用的医疗建议。您可以致电1-800-FDA-1088向FDA报告副作用。

Pregnancy & Breastfeeding

Can I takeJentadueto（Linagliptin和二甲双胍）if I’m pregnant or breastfeeding?

告诉医生您是否怀孕或母乳喂养。

遵循您的医生有关使用此药物的指示if you are pregnant or you become pregnant.在怀孕期间，控制糖尿病非常重要，血糖含量可能会导致母亲和婴儿的并发症。

这种药物可能会刺激绝经前女性排卵，并可能增加意外怀孕的风险。与您的医生谈谈您的风险。

剂量指南和提示

如何服用Jentadueto（Linagliptin和二甲双胍）？

UseJentadueto（Linagliptin和二甲双胍）完全按照指示标签,或规定by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

按照您的处方标签上的所有指示，阅读所有药物指南或说明表。完全按照指示使用药物。

除非您的医生告诉您，否则请服用Linagliptin和二甲双胍。

Swallow the tablet whole and do not crush, chew, or break it.

You may have low blood sugar(hypoglycemia)and feel very hungry, dizzy, irritable, confused, anxious, or shaky. To quickly treat hypoglycemia, eat or drink a fast-acting source of sugar (fruit juice, hard candy, crackers, raisins, or non-diet soda).

如果您患有严重的低血糖症，您的医生可能会开出胰高血糖素注射套件。确保您的家人或亲密的朋友知道如何在紧急情况下给您这种注射。

还要注意高血糖的迹象(hyperglycemia)例如口渴或排尿。

Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals.在更改剂量或药物时间表之前询问医生。

Linagliptin and metformin is only part of a complete treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.

在室温下存放远离水分和热量。

如果我错过了一剂，该怎么办Jentadueto（Linagliptin和二甲双胍）？

尽快服用药物（用食物），但是如果几乎该下一次剂量的时间，请跳过错过的剂量。Do nottake two doses at one time.

过量的标志

如果我服用过量会发生什么Jentadueto（Linagliptin和二甲双胍）？

If you think you or someone else may have overdosed on:Jentadueto（Linagliptin和二甲双胍），致电您的医生或毒物控制中心

（800）222-1222

如果有人倒下或没有呼吸Jentadueto（Linagliptin和二甲双胍），致电911

911

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