Omacetaxine (Synribo)
大辛汀用于治疗慢性髓样白血病（CML）。
Omacetaxine is given after at least two other cancer treatments did not work or have stopped working.
大辛汀也可以用于本药物指南中未列出的目的。
uses
什么是Omacetaxine (Synribo)used for?
- Chronic Myelogenous Leukemia
warnings
什么是the most important information I should know aboutOmacetaxine (Synribo)？
如果对它过敏，则不应使用omacetaine。
Tell your doctor if you have ever had:
- diabetes (in you or a family member); or
- bleeding problems.
大辛汀可能会伤害未出生的婴儿或导致出生缺陷如果母亲或父亲正在使用这种药物。
- If you are a woman,如果您怀孕，请勿使用omacetaine。在开始此治疗之前，您可能需要进行负妊娠测试。在您使用这种药物时，使用有效的节育措施预防怀孕，并在上次剂量后至少6个月。
- 如果你是男人如果您的性伴侣能够怀孕，请使用有效的节育。上次剂量后至少3个月继续使用节育措施。
- Tell your doctor right away if a pregnancy occurs while either the mother or the father is using omacetaxine.
This medicine may affect fertility (ability to have children) in men. However,it is important to use birth control to prevent pregnancy because omacetaxine can harm an unborn baby.
在使用这种药物时不要母乳喂养，and for at least 2 weeks after your last dose.
副作用
What are the side effects ofOmacetaxine (Synribo)？
Get emergency medical help if you have过敏反应的迹象：hives; difficult breathing; swelling of your face, lips, tongue, or throat.
如果有的话，请立即致电医生：
- ongoing nausea, stomach pain, or diarrhea;
- 容易瘀伤，异常出血（鼻子，嘴，阴道或直肠）；
- confusion, vision changes, slurred speech;
- blood in your urine, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
- 严重的皮疹或瘙痒；
- low red blood cells (anemia)- 皮肤，不寻常的疲倦，感觉浅或呼吸不足，手脚冷；
- high blood sugar- 口渴，排尿增加，口干，果味呼吸气味；或者
- signs of infection--fever, chills, tiredness, body aches, feeling short of breath.
Common side effects may include:
- 发烧，血细胞计数低；
- feeling weak or tired;
- 腹泻;
- nausea; or
- 注射药物的疼痛，肿胀或发红。
这不是副作用的完整列表，其他可能发生。打电话给您的医生，征求有关副作用的医疗建议。您可以致电1-800-FDA-1088向FDA报告副作用。
Pregnancy & Breastfeeding
Can I takeOmacetaxine (Synribo)if I’m pregnant or breastfeeding?
在使用这种药物时不要母乳喂养，and for at least 2 weeks after your last dose.
Interactions
我应该避免使用什么药物和食物Omacetaxine (Synribo)？
如果这种药物进入您的眼睛，请用水冲洗并立即致电医生。
避免靠近生病或感染的人。如果您产生感染迹象，请立即告诉医生。避免活动可能会增加您出血或受伤的风险。在剃须或刷牙时，请格外小心，以防止出血。
避免驾驶或危险活动，直到您知道这种药物会如何影响您。您的反应可能会受到损害。
剂量指南和提示
如何服用Omacetaxine (Synribo)？
UseOmacetaxine (Synribo)完全按照指示标签,或规定by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
按照您的处方标签上的所有指示，阅读所有药物指南或说明表。完全按照指示使用药物。
Omacetaxine is injected under the skin. A healthcare provider may teach you how to properly use the medication by yourself.
通常每12小时给予一次omacetaine。除非您的医生告诉您，否则请勿更改给药时间表或停止使用此药物。
Your healthcare provider will show you where on your body to inject omacetaxine. Use a different place each time you give an injection. Do not inject into the same place two times in a row.
您的注射将在药房准备，您将在预填充的注射器中收到药物。将这些注射器存放在冰箱中，不要冻结。如果您需要运输药物，请将注射器放在带有冰袋的冷却器中。
不要让这种药物与冰箱内的食物或饮料接触。
omacetaine混合物不含防腐剂。You must use a prefilled syringe within 6 days of when it was mixed at the pharmacy.
If a prefilled syringe reaches room temperature, you must use it within 12 hours after it was mixed.
Each vial (bottle) is for one use only. Throw it away after one use, even if there is still medicine left inside.
If this medicine accidentally gets on your skin, wash it thoroughly with soap and warm water.Anyone handling this medicine or giving you an injection should wear protective gloves and safety glasses.
仅使用针和注射器一次，然后将它们放入防线“锋利”容器中。遵循有关如何处置该容器的州或地方法律。将其远离儿童和宠物的范围。
If you need surgery or dental work, tell the surgeon ahead of time that you are using omacetaxine. You may need to stop using the medicine for a short time.
大辛汀可以降低血细胞，从而帮助您的身体抗击感染并帮助血液凝结。您的血液需要经常进行测试。您的癌症治疗可能会根据结果延迟。
跳过错剂量，并在常规时间使用下一个剂量。do not一次使用两剂。
If you are receiving this medicine in a clinic or cancer center, call your doctor for instructions if you miss an appointment for your omacetaxine injection.