asfotase alfa（皮下）
Asfotase alfa is an enzyme replacement medicine that is used to treat hypophosphatasia (HYE-poe-FOS-fa-TAY-zha).
下磷酸是一种罕见的遗传疾病，其中存在酶的缺乏，可以帮助人体过程钙和磷。这导致骨骼和牙齿的异常生长和发育，包括软或脆性骨骼，生长问题和牙齿脱落。
Asfotase alfa may also be used for purposes not listed in this medication guide.
警告
What is the most important information I should know aboutasfotase alfa（皮下）?
Before you use asfotase alfa, tell your doctor about all your medical conditions or allergies.
Tell your doctor if you are pregnant or breast-feeding.
Your name may be listed on a patient registry while you are using asfotase alfa. This is to track and evaluate any long-term effects of using this medicine.
Side Effects
什么是副作用asfotase alfa（皮下）?
如果有紧急医疗帮助过敏反应的迹象：hives; dizziness, nausea, vomiting; difficult breathing, choking sensation; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- vision changes;
- urinating more or less than usual;
- painful or difficult urination;
- pink, red, or brown urine; or
- 侧面或下背部剧烈疼痛。
Common side effects may include:
- pain, itching, swelling, redness, bruising, hardening, pitting, or other skin changes where the medicine was injected.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
怀孕和母乳喂养
Can I takeasfotase alfa（皮下）if I’m pregnant or breastfeeding?
Tell your doctor if you are pregnant or breast-feeding.
互动
What drugs and food should I avoid while takingasfotase alfa（皮下）?
Do not inject this medicine into skin areas that are red or swollen.
Dosage Guidelines & Tips
How to takeasfotase alfa（皮下）?
Useasfotase alfa（皮下）exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Asfotase alfa is usually given 3 to 6 times per week.Follow your doctor's dosing instructions very carefully.
Asfotase alfa is injected under the skin. A healthcare provider may teach you how to properly use the medication by yourself.
Read and carefully follow any Instructions for Use provided with your medicine.Ask your doctor or pharmacist if you don't understand all instructions.
Prepare an injection only when you are ready to give it.如果药物改变了颜色或中有颗粒，请勿使用。致电您的药剂师新药。
您可能需要使用2个小瓶和2个单独的注射器来组成这种药物的一剂。Follow your doctor's dosing instructions very carefully.
Your care provider will show you where on your body to inject asfotase alfa. Use a different place each time you give an injection. Do not inject into the same place two times in a row.
Asfotase alfa剂量基于体重（尤其是在儿童和青少年中）。如果您增加或减肥，您的剂量需求可能会改变。
你可能需要频繁的考试。
This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using asfotase alfa.
将这种药物存放在原始容器中，并在冰箱中保护，免受光保护。不要冻结或摇动这种药。
You may take the medicine out of the refrigerator and let it reach room temperature before injecting your dose.Do not leave the medicine out for longer than 1 hour.
每个小瓶（瓶）仅用于一次用途。一次用途后将其扔掉，即使里面仍然剩下药物。
Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.
Call your doctor for instructions if you miss a dose of asfotase alfa.