Austedo (Deutetrabenazine)
Deutetrabenazine is used to treat involuntary muscle movements (chorea) caused by Huntington's disease.Deutetrabenazine is not a cure for Huntington's disease and will not treat other symptoms of this condition.
Deutetrabenazine is used to treat symptoms of tardive dyskinesia, a nervous system disorder. Tardive dyskinesia causes repetitive uncontrolled muscle movements, usually in the face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement).
Deutetrabenazine is not a permanent cure for involuntary movement disorders.
Deutetrabenazine may also be used for purposes not listed in this medication guide.
warnings
What is the most important information I should know aboutAustedo (Deutetrabenazine)?
如果你都不应该使用deutetrabenazineergic to it, or if you have:
- untreated or uncontrolled depression;
- thoughts about suicide or hurting yourself;
- liver disease; or
- if you have recently taken tetrabenazine (Xenazine) or valbenazine (Ingrezza).
Do not use deutetrabenazine if you have taken reserpine (Serpalan, Renese-R) in the past 20 days, or if you have used an MAO inhibitor in the past 14 days.A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
Tell your doctor if you have ever had:
- depression, anxiety, nervousness, or agitation;
- mental illness or psychosis;
- suicidal thoughts or actions;
- breast cancer;
- a heart rhythm disorder;
- long QT syndrome (in you or a family member); or
- an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).
People with Huntington's disease may have a higherrisk of depression and suicidal thoughts or behaviors.Taking deutetrabenazine may further increase this risk. However, the benefits of taking this medicine (improvement in daily living) may outweigh any suicidal risks.
Taking deutetrabenazine may cause symptoms similar to Parkinson's disease (resting tremor, stiff muscles, slow movements, difficulty maintaining balance and walking).Ask your doctor about your risk.
Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.
Tell your doctor if you are pregnant or breastfeeding.
Side Effects
What are the side effects ofAustedo (Deutetrabenazine)?
Get emergency medical help if you havesigns of an allergic reaction:hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as: crying spells, changes in weight or appetite, feelings of low self-worth, loss of interest in things you once enjoyed, new sleep problems, or if you feel hopeless, guilty, extremely tired, irritable, hostile, aggressive, or have thoughts about suicide or hurting yourself.
Some side effects may actually be signs that your Huntington's disease is progressing.Your doctor will need to check your progress at regular intervals.
打电话给你的医生如果你哈ve:
- fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);
- pain or burning when you urinate;
- severe restlessness or agitation;
- tremors, shaking;
- muscle stiffness;
- problems with balance or coordination; or
- severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.
Common side effects may include:
- drowsiness;
- feeling tired;
- dry mouth;
- runny or stuffy nose, sore throat;
- sleep problems (insomnia); or
- diarrhea.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I takeAustedo (Deutetrabenazine)if I’m pregnant or breastfeeding?
Tell your doctor if you are pregnant or breastfeeding.
Interactions
What drugs and food should I avoid while takingAustedo (Deutetrabenazine)?
Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Dizziness or severe drowsiness can cause falls or other accidents.
Drinking alcohol with this medicine can cause side effects.
Dosage Guidelines & Tips
How to takeAustedo (Deutetrabenazine)?
UseAustedo (Deutetrabenazine)exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
If you are switching from a similar medicine called tetrabenazine (Xenazine),take your first dose of deutetrabenazine one day after your last dose of tetrabenazine.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Deutetrabenazine is usually taken 1 or 2 times per day with food and a whole glass of water.
Swallow the tablet whole and do not crush, chew, or break it. Tell your doctor if you have trouble swallowing the tablet whole.
Your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG).
Do not stop taking deutetrabenazine without first asking your doctor.If you stop taking deutetrabenazine for longer than 1 week, do not start taking it again without your doctor's advice.
Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose.Do nottake two doses at one time.
Overdose Signs
What happens if I overdose onAustedo (Deutetrabenazine)?
Overdose symptoms may include tremors or severe muscle stiffness, rapid eye movements, vomiting, sweating, severe drowsiness, confusion, hallucinations, diarrhea, or feeling light-headed.
Images
SD 12
Color: beige
Shape: round
Form: film coated
Imprint: SD 12
SD 9
Color: blue
Shape: round
Form: film coated
Imprint: SD 9
SD 6
Color: purple
Shape: round
Form: film coated
Imprint: SD 6