Cometriq (Oral)
Cabometyxis used to treat advanced kidney cancer, sometimes in combination with another medicine called nivolumab.
Cabometyxis also used to treat liver cancer in people who have been previously treated with sorafenib.
Cometriqis used to treat thyroid cancer that has spread to other parts of the body.
Cabozantinib may also be used for purposes not listed in this medication guide.
warnings
What is the most important information I should know aboutCometriq (Oral)?
Tell your doctor if you have:
- an open wound on your skin (or a wound that is still healing);
- bleeding problems (such as bloody or tarry stools, or coughing up blood or vomit that looks like coffee grounds);
- high blood pressure;
- liver disease; or
- a pre-existing dental problem.
You may need to have a negative pregnancy test before starting this treatment.
Cabozantinib may harm an unborn baby.Use effective birth control to prevent pregnancy while you are using this medicine and for at least 4 months after your last dose. Tell your doctor if you think you might be pregnant.
This medicine may affect fertility (ability to have children) in both men and women. However,it is important to use birth control to prevent pregnancy because cabozantinib can harm an unborn baby.
You should not breastfeed while using this medicine, and for at least 4 months after your last dose.
Side Effects
What are the side effects ofCometriq (Oral)?
Get emergency medical help if you havesigns of an allergic reaction:hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Cabozantinib may cause a perforation (a hole or tear) or a fistula (an abnormal passageway) within your stomach or intestines.Call your doctor if you have severe stomach pain, or if you feel like you are choking and gagging when you eat or drink.
马上打电话给你的医生如果你有:
- severe headache, blurred vision, pounding in your neck or ears;
- vomiting, diarrhea, or constipation that are severe and ongoing;
- swelling in your hands, arms, legs, or feet;
- easy bruising or bleeding (nosebleeds, bleeding gums, heavy menstrual bleeding, or any bleeding that will not stop);
- bloody or tarry stools, cough with bloody mucus or vomit that looks like coffee grounds;
- jaundice (yellowing of the skin or eyes);
- pain, blisters, bleeding, or severe rash in the palms of your hands or the soles of your feet;
- confusion, thinking problems, weakness, vision changes, seizure;
- a light-headed feeling, like you might pass out;
- jaw pain or numbness, red or swollen gums, loose teeth, or slow healing after dental work;
- low white blood cell counts--fever, mouth sores, skin sores, sore throat, cough, trouble breathing;
- adrenal gland problems--nausea, vomiting, extreme tiredness, dizziness, weakness, fainting; or
- signs of a stroke or blood clot--sudden numbness or weakness on one side of your body, problems with vision or balance, trouble speaking or understanding what is said to you, chest pain, trouble breathing, swelling or pain in an arm or leg.
Your future doses of cabozantinib may be delayed or permanently discontinued if you have certain side effects.
Common side effects may include:
- stomach pain, nausea, vomiting, loss of appetite, diarrhea, constipation;
- pain, redness, swelling, or sores in your mouth or throat;
- trouble speaking, changes in taste;
- cold symptoms such as stuffy nose, sneezing, sore throat, cough;
- rash;
- pain in your muscles, bones, and joints;
- abnormal liver function tests or other blood tests;
- feeling tired;
- weight loss; or
- hair color turning lighter.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I takeCometriq (Oral)if I’m pregnant or breastfeeding?
You may need to have a negative pregnancy test before starting this treatment.
Cabozantinib may harm an unborn baby.Use effective birth control to prevent pregnancy while you are using this medicine and for at least 4 months after your last dose. Tell your doctor if you think you might be pregnant.
You should not breastfeed while using this medicine, and for at least 4 months after your last dose.
Interactions
What drugs and food should I avoid while takingCometriq (Oral)?
Grapefruit may interact with cabozantinib and lead to unwanted side effects.Avoid the use of grapefruit products while taking cabozantinib.
Avoid taking an herbal supplement containing St. John's wort.
Dosage Guidelines & Tips
How to takeCometriq (Oral)?
UseCometriq (Oral)exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
遵循处方标签上各个方向nd read all medication guides or instruction sheets. Use the medicine exactly as directed.
Do not use cabozantinib tablets in place of cabozantinib capsules.Take only the pill form your doctor has prescribed.Avoid medication errors by always checking the medicine you receive at the pharmacy.
Take cabozantinib on an empty stomach, at least 1 hour before or 2 hours after you eat anything.
Do not take this medicine with food.
Take this medicine with a full glass of water.
Do not crush, chew, or break a tablet, and do not open a capsule. Swallow the pill whole.
When used withCabometyx,nivolumab is usually given as an infusion into a vein once every 2 to 4 weeks.
Your blood pressure and liver function may need to be checked often.
If you need surgery or dental work, stop taking cabozantinib at least 3 weeks ahead of time. After a surgery or dental procedure, you may need to wait 2 weeks before you start taking cabozantinib again.Follow your doctor's dosing instructions very carefully.
If you have stopped taking cabozantinib for any reason,talk with your doctor before you start taking it again.
Store at room temperature away from moisture and heat.
Take the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 12 hours.Do notuse two doses at one time.