Conjugated Estrogens And Medroxyprogesterone (Oral)

Drugs & Supplements

Conjugated Estrogens And Medroxyprogesterone (Oral)

Brand Names: Premphase,Prempro
Reviewed:

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body. Conjugated estrogens are a mixture of estrogen hormones.

Medroxyprogesterone is a form of progesterone, a female hormone important for regulating ovulation and menstruation.

Conjugated estrogens and medroxyprogesterone is a combination medicine used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women.

Conjugated estrogens and medroxyprogesterone may also be used for purposes not listed in this medication guide.

uses

What isConjugated Estrogens And Medroxyprogesterone (Oral)used for?

  • Atrophic Urethritis
  • Atrophic Vaginitis
  • Osteoporosis
  • Postmenopausal Symptoms

warnings

What is the most important information I should know aboutConjugated Estrogens And Medroxyprogesterone (Oral)?

You should not use this medicine if you have:

  • unusual vaginal bleeding that has not been checked by a doctor;
  • liver disease;
  • a history of heart attack, stroke, or blood clot;
  • an increased risk of having blood clots due to a heart problem or a hereditary blood disorder; or
  • a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina.

Do not use conjugated estrogens and medroxyprogesterone if you are pregnant.Tell your doctor right away if you become pregnant during treatment.

Using this medicine can increase your risk of blood clots, stroke, or heart attack.You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke.

Conjugated estrogens and medroxyprogesterone should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions.

Tell your doctor if you have ever had:

  • a hysterectomy;
  • heart disease;
  • liver problems, or jaundice caused by pregnancy or taking hormones;
  • kidney disease;
  • gallbladder disease;
  • asthma;
  • epilepsy or other seizure disorder;
  • migraines;
  • lupus;
  • endometriosis or uterine fibroid tumors;
  • hereditary angioedema;
  • porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system);
  • a thyroid disorder; or
  • high levels of calcium in your blood.

Using this medicine may increase your risk of cancer of the breast, uterus, or ovaries. Talk with your doctor about this risk.

Estrogen lowers the hormone needed to produce breast milk and can slow breast milk production. Tell your doctor if you are breast-feeding.

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Side Effects

What are the side effects ofConjugated Estrogens And Medroxyprogesterone (Oral)?

Get emergency medical help if you havesigns of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

马上打电话给你的医生如果你有:

  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
  • signs of a blood clot--sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;
  • swelling or tenderness in your stomach;
  • jaundice (yellowing of the skin or eyes);
  • memory problems, confusion, unusual behavior;
  • unusual vaginal bleeding, pelvic pain;
  • a lump in your breast; or
  • high levels of calcium in your blood--nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, lack of energy.

Common side effects may include:

  • nausea, gas, stomach pain;
  • headache, back pain;
  • depression, weakness;
  • breast pain;
  • itching, thinning scalp hair; or
  • vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pregnancy & Breastfeeding

Can I takeConjugated Estrogens And Medroxyprogesterone (Oral)if I’m pregnant or breastfeeding?

Contraindicated in pregnancy
Based on FDA pregnancy categories

Do not use conjugated estrogens and medroxyprogesterone if you are pregnant.Tell your doctor right away if you become pregnant during treatment.

Estrogen lowers the hormone needed to produce breast milk and can slow breast milk production. Tell your doctor if you are breast-feeding.

Interactions

What drugs and food should I avoid while takingConjugated Estrogens And Medroxyprogesterone (Oral)?

Avoid smoking. It can greatly increase your risk of blood clots, stroke, or heart attack while using this medicine.

Grapefruit may interact with conjugated estrogens and medroxyprogesterone and lead to unwanted side effects.Avoid the use of grapefruit products.

Dosage Guidelines & Tips

How to takeConjugated Estrogens And Medroxyprogesterone (Oral)?

UseConjugated Estrogens And Medroxyprogesterone (Oral)完全按照指示标签,或规定by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take the medicine at the same time each day.

Conjugated estrogens and medroxyprogesterone may increase your risk of developing a condition that may lead to uterine cancer. Your doctor may prescribe a progestin to take while you are using this medicine, to help lower this risk.Report any unusual vaginal bleeding right away.

The 28-dayPremphasetreatment consists of two differently colored pills, 14 of each color. Carefully follow the patient instructions about which pills to take on days 1 through 14 and which pills to take on days 15 through 28.

Your doctor should check your progress on a regular basis to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis, and have regular mammograms.

If you need major surgery or will be on long-term bed rest,you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using conjugated estrogens and medroxyprogesterone.

Store at room temperature away from moisture, heat, and light.

What should I do if I missed a dose ofConjugated Estrogens And Medroxyprogesterone (Oral)?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose.Do nottake two doses at one time.

Overdose Signs

What happens if I overdose onConjugated Estrogens And Medroxyprogesterone (Oral)?

If you think you or someone else may have overdosed on:Conjugated Estrogens And Medroxyprogesterone (Oral), call your doctor or the Poison Control center
(800) 222-1222
If someone collapses or isn't breathing after takingConjugated Estrogens And Medroxyprogesterone (Oral),拨打911
911

Images

PREMPRO 0.3/1.5

Color: yellow

Shape: oval

Imprint: PREMPRO 0.3/1.5

PREMPRO 0.45/1.5

Color: yellow

Shape: oval

Imprint: PREMPRO 0.45/1.5

PREMPRO 0.625/2.5

Color: orange

Shape: oval

Imprint: PREMPRO 0.625/2.5

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Medical Disclaimer

Drugs A-Z provides drug information from Everyday Health and our partners, as well as ratings from our members, all in one place. Cerner Multum™ provides the data within some of the Overview, Uses, Warnings, Side Effects, Pregnancy, Interactions, Dosage, Overdose, and Images sections. The information within all other sections is proprietary to Everyday Health.
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