Canagliflozin和二甲双胍is a combination medicine used with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.
卡纳氏菌素和二甲双胍也用于降低患有心脏病的2型糖尿病成人心脏病发作，中风或心力衰竭死亡的风险。
Canagliflozin和二甲双胍is also used to reduce the risk of end-stage kidney disease and hospitalization or death from heart problems in adults who also have kidney problems caused by type 2 diabetes.
这种药物不用于治疗1型糖尿病。
Canagliflozin和二甲双胍也可以用于本药物指南中未列出的目的。
uses
What isInvokamet（Canagliflozin和二甲双胍）用于？
- 糖尿病Type 2
- 糖尿病
- 糖尿病昏迷（在DM II类中）
- Diabetic Ketoacidosis (in DM Type II)
警告
我应该知道的最重要的信息是什么Invokamet（Canagliflozin和二甲双胍）?
You should not use this medicine if you are allergic to canagliflozin or metformin, or if you have:
- severe kidney disease; or
- ketoacidosis (call your doctor for treatment).
If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking canagliflozin and metformin.
Canagliflozin可能会增加您的下腿截肢的风险，especially if you have had a prior amputation, a foot ulcer, heart disease, circulation problems, or nerve damage.
告诉医生您是否曾经有：
- 心脏问题;
- a diabetic foot ulcer or amputation;
- 腿或脚的循环问题或神经问题；
- liver or kidney disease;
- low levels of vitamin B12 or calcium in your blood;
- 膀胱感染或其他排尿问题；
- a pancreas disorder or surgery;
- a change in your diet; or
- 如果您正在低盐饮食。
您可能会发展乳酸性酸中毒，血液中乳酸的危险积聚。如果您患有其他医疗状况，严重的感染，慢性酒精中毒或65岁或65岁以上，则可能更有可能。向您的医生询问您的风险。
Tell your doctor right away if you become pregnant.如果您在妊娠中期或三个月服用这种药物，Canagliflozin可能会伤害未出生的婴儿。
Metformin may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.
使用这种药物时，您不应母乳喂养。
Canagliflozin和二甲双胍is not approved for use by anyone younger than 18 years old.
副作用
什么是副作用Invokamet（Canagliflozin和二甲双胍）?
如果有紧急医疗帮助过敏反应的迹象：麻疹;呼吸困难；脸部，嘴唇，舌头或喉咙肿胀。
如果您有生殖器感染的迹象（阴茎或阴道），请立即寻求医疗护理：生殖器或直肠区域的燃烧，瘙痒，气味，排放，疼痛，压痛，发红或肿胀，发烧，感觉不舒服。这些症状可能会迅速恶化。
Mild symptoms of lactic acidosis may worsen over time, and this condition can be fatal. Stop taking this medicine and call your doctor right away if you have unusual muscle pain, trouble breathing, stomach pain, vomiting, irregular heart rate, dizziness, feeling cold, or feeling very weak or tired.
Call your doctor at once if you have:
- 腿或脚的新疼痛，压痛，疮，溃疡或感染；
- 几乎没有排尿；
- 昏昏欲睡的感觉，就像你可能昏倒的那样；
- 高钾水平--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, muscle weakness;
- 酮症酸中毒(血液中过多的酸)--nausea, vomiting, stomach pain, confusion, unusual drowsiness, or trouble breathing; or
- signs of a bladder infection--pain or burning when you urinate, urine that looks cloudy, pain in pelvis or back.
服用这种药物时，老年人可能更有可能脱水或肾脏问题。
使用这种药物时，您可能更有可能骨折。与您的医生谈谈如何避免骨折的风险。
常见的副作用可能包括：
- urinating more than usual;
- 头痛，弱点；
- 气体，胃痛，消化不良；
- nausea, vomiting; or
- 腹泻。
这不是副作用的完整列表，其他可能发生。打电话给您的医生，征求有关副作用的医疗建议。您可以致电1-800-FDA-1088向FDA报告副作用。
怀孕和母乳喂养
我能拿吗Invokamet（Canagliflozin和二甲双胍）如果我怀孕还是母乳喂养？
Tell your doctor right away if you become pregnant.如果您在妊娠中期或三个月服用这种药物，Canagliflozin可能会伤害未出生的婴儿。
Metformin may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.
使用这种药物时，您不应母乳喂养。
Interactions
What drugs and food should I avoid while takingInvokamet（Canagliflozin和二甲双胍）?
Avoid drinking alcohol. It lowers blood sugar and may increase your risk of lactic acidosis.
Dosage Guidelines & Tips
How to takeInvokamet（Canagliflozin和二甲双胍）?
利用Invokamet（Canagliflozin和二甲双胍）完全按照标签或医生的规定。不要在较大或较小的量或更长的时间内使用。
If you had been taking an evening dose of metformin extended-release tablets, skip your last dose the evening before you start taking canagliflozin and metformin.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
吃食物。
吞下扩展释放平板电脑整个，不要粉碎，咀嚼或打破它。
您可能患有低血糖（低血糖）并感到非常饥饿，头晕，易怒，困惑，焦虑或摇晃。快速治疗低血糖，吃或喝糖的快速源（果汁，硬糖，饼干，葡萄干或非含水苏打）。
Your doctor may prescribe a glucagon injection kit in case you have severe hypoglycemia. Be sure your family or close friends know how to give you this injection in an emergency.
还要注意高血糖的迹象（高血糖）such as increased thirst or urination.
血糖水平可能会受到压力，疾病，手术，运动，饮酒或跳过餐的影响。在更改剂量或药物时间表之前询问医生。
Your doctor may have you take extra vitamin B12. Take only the amount of vitamin B12 that your doctor has prescribed.
打电话给你的医生如果你有持续的呕吐或diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medicine, which can lead to severely low blood pressure or a serious electrolyte imbalance.
If you need surgery or medical tests, tell any doctor who treats you that you are using canagliflozin and metformin.You may need to stop using this medicine at least 3 days before a surgery.Ask your doctor about how to control your blood sugar during this time.
Canagliflozin和二甲双胍只是治疗计划的一部分，该计划还可能包括饮食，运动，体重控制，血糖测试和特殊的医疗服务。非常仔细地遵循医生的指示。
Store tablets in their original container at room temperature, away from moisture and heat. Do not keep canagliflozin and metformin tablets in a daily pill box for longer than 30 days.
Take the medicine (with food) as soon as you can, but skip the missed dose if it is almost time for your next dose.不要一次服用两剂。
过量的标志
What happens if I overdose onInvokamet（Canagliflozin和二甲双胍）?
Images
CM, 155
Color： 白色的
形状: capsule
Form：胶片涂层
烙印：CM，155
CM，215
Color： 黄色
形状: capsule
Form：胶片涂层
烙印: CM, 215
CM，551
Color: beige
形状: capsule
Form：胶片涂层
烙印: CM, 551