Kymriah (Ped ALL)(Intravenous)
Tisagenlecleucel是一种免疫疗法药物，用于治疗一定类型的急性淋巴细胞白血病，患者最多25岁。在其他治疗失败后给予这种药。
Tisagenlecleucel.is made using white blood cells removed from blood that is drawn from your body through a vein.
Tisagenlecleucel.is available under a special program. You must be registered in the program and understand the risks and benefits of this medicine.
Tisagenlecleucel也可用于该药物指南中未列出的目的。
warnings
什么是the most important information I should know aboutKymriah (Ped ALL)(Intravenous)还
Tell your doctor if you have ever had:
- 乙型肝炎或c;
- 艾滋病毒（人免疫缺陷病毒）;要么
- 如果您在过去的两周内收到了疫苗。
在接受这种药之前，女性可能需要怀孕测试。在用Tisagenlecleulel和化学疗法治疗后，您可能还需要使用避孕治疗以防止怀孕。
如果您在怀孕期间收到Tisagenlecleucel，那么您的婴儿的血液可能需要在出生后进行测试。这是评估药物可能对婴儿的任何影响。
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
副作用
What are the side effects ofKymriah (Ped ALL)(Intravenous)还
Get emergency medical help if you have过敏反应的迹象：hives; difficult breathing; swelling of your face, lips, tongue, or throat.
A serious side effect of tisagenlecleucel is called cytokine release syndrome (CRS)。如果您有这种情况的迹象，请立即告诉您的照顾者：发烧，寒意，呼吸，身体疼痛，呕吐，腹泻或感觉轻弹。Your caregivers will have medication available to quickly treat CRS if it occurs.
Also如果您有威胁性神经问题的迹象，请告诉您的照顾者或寻求紧急医疗注意：problems with speech, problems with thinking or memory, confusion, or a seizure.
Also call your doctor at once if you have:
- 头痛，异常疲倦;
- tremors, anxiety, agitation;
- 不寻常的想法或行为;
- trouble speaking or understanding what is said to you; or
- signs of infection--fever，寒冷，流感症状，口疮，皮肤溃疡，易瘀伤或出血，咳嗽，呼吸困难。
Common side effects may include:
- 恶心，呕吐，腹泻，食欲丧失;
- fever;
- headache, confusion, feeling tired;
- 流血的;要么
- fast heartbeats.
这不是一个完整的副作用列表，其他可能会发生。打电话给您的医生，征求有关副作用的医疗建议。您可以在1-800-FDA-1088向FDA报告副作用。
Pregnancy & Breastfeeding
Can I takeKymriah (Ped ALL)(Intravenous)if I’m pregnant or breastfeeding?
在接受这种药之前，女性可能需要怀孕测试。在用Tisagenlecleulel和化学疗法治疗后，您可能还需要使用避孕治疗以防止怀孕。
如果您在怀孕期间收到Tisagenlecleucel，那么您的婴儿的血液可能需要在出生后进行测试。这是评估药物可能对婴儿的任何影响。
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
Interactions
在服用时，我应该避免哪些药物和食物Kymriah (Ped ALL)(Intravenous)还
这种药会导致弱点，嗜睡，困惑，记忆或协调问题，并癫痫发作。在用Tisagenlecleucel治疗后，避免驾驶或运行机械至少8周。
Ask your doctor before you receive a "live" vaccine.活疫苗包括麻疹，腮腺炎，风疹（MMR），脊髓灰质炎，轮状病病毒，伤寒，黄热病，水痘（水痘），带状疱疹（带状疱疹）和鼻腔流感（流感）疫苗。
Do not donate blood, an organ, or any tissues or cells from your own body.
剂量指南和提示
如何服用Kymriah (Ped ALL)(Intravenous)还
UseKymriah (Ped ALL)(Intravenous)exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Tisagenlecleucel仅在授权的医院或诊所提供，必须由经过特殊培训的医疗保健专业人员提供。
Tisagenlecleucel是在称为白瓜睾丸睾丸（LOO-KUH-FUH-REE-SIS）的过程后给出的。
leukapheresis期间,你的一些血is collected through a small tube (catheter) placed into a vein. The catheter is connected to a machine that separates your white blood cells from other parts of the blood.
然后将细胞送至实验室，其中它们被制成Tisagenleclecel。因为将血细胞加入Tisagenlecleulel时需要时间，因为您不会在血细胞被吸取的那一天收到药物。
在给出了Tisagenlecleucel之前约2至14天，您将预处理化疗，以帮助为Tisagenlecleul的身体做好准备。
就在收到Tisagenlecleucel之前，您将获得其他药物，以帮助防止严重的副作用或过敏反应。
一旦您的身体准备接收TisagenleCleucel，您的护理商会通过IV将药物注入静脉。
For at least 4 weeks, plan to stay near the hospital or clinic where you received tisagenlecleucel. Avoid being so far away that it takes you longer than 2 hours to travel back to the hospital.
注射后可能发生严重且有时致命感染可能会发生。Call your doctor right away if you havefever, chills, easy bruising, unusual bleeding, or other signs of infection.
该药可导致您对HIV（人类免疫缺陷病毒）具有假辐射检查。告诉任何对待您使用Tisagenlecleucel的医生。
Using tisagenlecleucel may increase your risk of developing other types of cancer, or causing your leukemia to come back. Your doctor will need to check your progress for the rest of your life.
If you have ever had hepatitis B, tisagenlecleucel can cause this condition to come back or get worse.您需要经常验证治疗期间的肝功能，并在使用此药物后几个月。
Call your doctor for instructions if you miss any of your chemotherapy treatment, or if you miss a dose of your medications to prevent side effects of tisagenlecleucel.
过量标志
如果我过量发作，会发生什么Kymriah (Ped ALL)(Intravenous)还
Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.