You should not use estropipate if you are allergic to it, or if you have:
- unusual vaginal bleeding that has not been checked by a doctor;
- liver disease;
- a history of heart attack, stroke, or blood clot; or
- a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina.
Do not use estropipate if you are pregnant.Tell your doctor right away if you become pregnant during treatment.
Using estropipate can increase your risk of blood clots, stroke, or heart attack.You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke.
Estropipate should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions.
Tell your doctor if you have ever had:
- a hysterectomy;
- heart disease;
- liver problems, or jaundice caused by pregnancy or taking hormones;
- a thyroid disorder;
- gallbladder disease;
- kidney disease;
- asthma;
- epilepsy or other seizure disorder;
- migraine headaches;
- lupus;
- endometriosis or uterine fibroid tumors;
- high levels of calcium in your blood; or
- porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system).
Using estropipate may increase your risk of cancer of the breast, uterus, or ovaries. Talk with your doctor about this risk.
Estropipate can slow breast milk production. Tell your doctor if you are breast-feeding.
