Zelboraf(Oral)
Vemurafenib is used to treat melanoma (skin cancer) that has spread to other parts of the body or cannot be removed by surgery.
Vemurafenib is also used to treat Erdheim-Chester Disease (a rare blood cancer).
Vemurafenib is used only if your cancer has a specific genetic marker (an abnormal "BRAF" gene). Your doctor will test you for this gene.
Vemurafenib may also be used for purposes not listed in this medication guide.
uses
What isZelboraf(Oral)used for?
- Melanoma -- Metastatic
- Histiocytosis
warnings
What is the most important information I should know aboutZelboraf(Oral)?
You should not use vemurafenib if you are allergic to it.
Tell your doctor if you have ever had:
- liver or kidney disease;
- heart problems;
- long QT syndrome (in you or a family member); or
- an electrolyte imbalance (such as low levels of calcium, potassium, or magnesium in your blood).
Tell your doctor about all radiation treatments you are scheduled to receive, or have received in the past.
Using vemurafenib may increase your risk of developing other types of skin cancer. Report any new or worsening skin lesions to your doctor right away.
Vemurafenib may harm an unborn baby.Use effective birth control to prevent pregnancy while you are using this medicine, and for 2 weeks after your last dose. Tell your doctor if you become pregnant.
Do not breastfeed while using this medicine,and for at least 2 weeks after your last dose.
Side Effects
What are the side effects ofZelboraf(Oral)?
Get emergency medical help if you havesigns of an allergic reaction(hives, difficult breathing, swelling in your face or throat)or a severe skin reaction(fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body.Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.
Stop using vemurafenib and call your doctor at once if you have:
- skin changes--a new wart or lesion, a skin sore or red bump that bleeds or does not heal, or any change in the size or color of a mole;
- 不寻常的增厚的皮肤组织the palms of your hands or the soles of your feet;
- a finger or fingers that feel tight or are bent inward;
- fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);
- 眼睛的问题--vision changes, eye pain or swelling, severe eye redness, small white or yellow patches on the surface of your eye; or
- liver problems--stomach pain (upper right side), nausea, vomiting, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Common side effects may include:
- joint pain;
- feeling tired;
- nausea;
- hair loss;
- mild rash or itching;
- skin growths; or
- sunburn, increased sensitivity to sunlight.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I takeZelboraf(Oral)if I’m pregnant or breastfeeding?
Vemurafenib may harm an unborn baby.Use effective birth control to prevent pregnancy while you are using this medicine, and for 2 weeks after your last dose. Tell your doctor if you become pregnant.
Do not breastfeed while using this medicine,and for at least 2 weeks after your last dose.
Interactions
What drugs and food should I avoid while takingZelboraf(Oral)?
Vemurafenib could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Dosage Guidelines & Tips
How to takeZelboraf(Oral)?
UseZelboraf(Oral)exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Take the medicine every 12 hours, with or without food.
Swallow the tablet whole and do not crush, chew, or break it.
If you vomit shortly after taking vemurafenib, do not take another dose. Wait until your next scheduled dose time to take the medicine again.
You will need frequent medical tests.
To make sure vemurafenib is not causing harmful effects, your skin condition will need to be checked often. Your heart function may also need to be tested with an electrocardiogram (ECG or EKG) on a regular basis. You may also need eye exams.你的癌症治疗可能be delayed based on the results of these tests.
Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
Your doctor may want to check your skin for several months after you stop using vemurafenib.Visit your doctor regularly.
Use the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 4 hours.Do notuse two doses at one time.
Overdose Signs
What happens if I overdose onZelboraf(Oral)?
Images
VEM
Color: pink
Shape: oval
Form: film coated
Imprint: VEM