Abbokinase (Intravenous)
Urokinase is a thrombolytic (THROM-bo-LIT-ik) drug, sometimes called a "clot-busting" drug. It helps your body produce a substance that dissolves unwanted blood clots.
Urokinase is used to treat blood clots in the lungs.
Urokinase may also be used for purposes not listed in this medication guide.
uses
What isAbbokinase (Intravenous)used for?
- Pulmonary Embolism
- Heart Disease
- Pulmonary Impairment
- Pulmonary Heart or Vascular Disease
- Pulmonary Thromboembolism
- Thromboembolic Pulmonary Hypertension
warnings
What is the most important information I should know aboutAbbokinase (Intravenous)?
You should not be treated with urokinase if you are allergic to it, or if you have:
- 活跃体内出血;
- a brain tumor or blood vessel disorder;
- a brain aneurysm (dilated blood vessel);
- a bleeding or blood clotting disorder (such as hemophilia);
- severe or uncontrolled high blood pressure;
- if you have had a recent medical emergency requiring CPR (cardiopulmonary resuscitation); or
- if you have had a stroke, brain surgery, or spinal surgery within in the past 2 months.
If possible before you receive urokinase, tell your doctor if you have:
- a history of stroke;
- severe liver or kidney disease;
- eye problems caused by diabetes;
- an infection of the lining of your heart (also called bacterial endocarditis);
- a blood clot of your heart;
- a recent history of stomach or intestinal bleeding;
- if you are pregnant or have had a baby within the past 10 days; or
- if you have had surgery or an organ transplant within the past 10 days.
In an emergency situation it may not be possible to tell your caregivers if you are pregnant or breast-feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medicine.
Urokinase is made from human plasma (part of the blood) which may contain viruses and other infectious agents. Donated plasma is tested and treated to reduce the risk of it containing infectious agents, but there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medication.
Side Effects
What are the side effects ofAbbokinase (Intravenous)?
Get emergency medical help if you havesigns of an allergic reaction:hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Urokinase increases your risk of bleeding, which can be severe or life-threatening.Call your doctor or seek emergency medical attention if you have bleeding that will not stop. Bleeding may occur from a surgical incision, or from the skin where a needle was inserted during a blood test or while receiving injectable medication. You may also have bleeding on the inside of your body, such as in your stomach or intestines, kidneys or bladder, brain, or within the muscles.
Call your doctor at once if you have signs of bleeding inside your body, such as:
- easy bruising or bleeding (nosebleeds, bleeding gums, bleeding from a wound, incision, catheter, or needle injection);
- bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
- red or pink urine; or
- sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance.
Some side effects may occur during or within 1 hour after the injection. Tell your caregiver right away if you feel chilled or feverish, nauseated, light-headed, or have chest tightness, back pain, trouble breathing, or fast heartbeats.
Also call your doctor at once if you have:
- chest pain or heavy feeling, pain spreading to the jaw or shoulder, nausea, sweating, general ill feeling;
- swelling, rapid weight gain, little or no urinating;
- severe stomach pain, nausea, and vomiting;
- darkening or purple discoloration of your fingers or toes;
- very slow heartbeats, shortness of breath, feeling light-headed;
- sudden severe back pain, muscle weakness, numbness or loss of feeling in your arms or legs;
- dangerously high blood pressure--severe headache, blurred vision, pounding in your neck or ears, nosebleed, anxiety, confusion, severe chest pain, shortness of breath, irregular heartbeats; or
- pancreatitis--severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I takeAbbokinase (Intravenous)if I’m pregnant or breastfeeding?
In an emergency situation it may not be possible to tell your caregivers if you are pregnant or breast-feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medicine.
Interactions
What drugs and food should I avoid while takingAbbokinase (Intravenous)?
Ask your doctor before taking aspirin or ibuprofen(Motrin, Advil) shortly after you have received urokinase. These medications can increase your risk of bleeding.
Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.
Dosage Guidelines & Tips
How to takeAbbokinase (Intravenous)?
UseAbbokinase (Intravenous)exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Urokinase is injected into a vein through an IV. A healthcare provider will give you this injection.
Urokinase is given slowly, usually over a period of 12 hours, using a continuous infusion pump.
Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely while you are receiving urokinase.
After treatment with urokinase,your doctor may prescribe a blood thinner or other medication to help prevent future blood clots.车efully follow all dosing instructions. These medications can make it easier for you to bleed, even from a minor injury.
Because you will receive urokinase in a clinical setting, you are not likely to miss a dose.
Overdose Signs
What happens if I overdose onAbbokinase (Intravenous)?
Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.