Urokinase (Abbokinase)
尿激酶是一种溶栓（Throm-bo-Lit-ik）药物，有时被称为“凝块破坏”药物。它可以帮助您的身体产生溶解不良血凝块的物质。
Urokinase is used to treat blood clots in the lungs.
尿蛋白酶也可以用于本药物指南中未列出的目的。
warnings
什么是the most important information I should know aboutUrokinase (Abbokinase)？
如果您对它过敏，或者如果有：
- 体内积极出血；
- a brain tumor or blood vessel disorder;
- a brain aneurysm (dilated blood vessel);
- a bleeding or blood clotting disorder (such as hemophilia);
- severe or uncontrolled high blood pressure;
- if you have had a recent medical emergency requiring CPR (cardiopulmonary resuscitation); or
- 如果您在过去两个月内进行了中风，脑手术或脊柱手术。
If possible before you receive urokinase, tell your doctor if you have:
- 中风的历史；
- 严重的肝脏或肾脏疾病；
- 糖尿病引起的眼睛问题；
- 感染您的心脏壁膜（也称为细菌性心内膜炎）；
- 你内心的血块；
- a recent history of stomach or intestinal bleeding;
- 如果您在过去的10天内怀孕或生了婴儿；或者
- 如果您在过去10天内进行了手术或器官移植。
In an emergency situation it may not be possible to tell your caregivers if you are pregnant or breast-feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medicine.
尿激酶是由人血浆（血液的一部分）制成的，可能含有病毒和其他感染剂。对捐赠的血浆进行了测试和处理，以降低含有传染剂的风险，但仍然很可能会传播疾病。与您的医生谈谈使用这种药物的风险和好处。
副作用
What are the side effects ofUrokinase (Abbokinase)？
Get emergency medical help if you have过敏反应的迹象：hives; difficult breathing; swelling of your face, lips, tongue, or throat.
尿激酶会增加出血的风险，这可能是严重或威胁生命的。如果您流血不会停止，请致电您的医生或寻求紧急医疗护理。可能是从外科手术切口或在血液检查期间插入针头或接受注射药物的皮肤的出血。您可能还会在身体内部出血，例如在胃或肠道，肾脏或膀胱，大脑或肌肉中。
如果您体内有出血的迹象，请立即致电医生，例如：
- 容易瘀伤或出血（流鼻血，牙龈出血，伤口出血，切口，导管或针头注射）；
- 血腥或磨砂膏，咳嗽的血液或呕吐物看起来像咖啡斑；
- red or pink urine; or
- sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance.
Some side effects may occur during or within 1 hour after the injection. Tell your caregiver right away if you feel chilled or feverish, nauseated, light-headed, or have chest tightness, back pain, trouble breathing, or fast heartbeats.
Also call your doctor at once if you have:
- chest pain or heavy feeling, pain spreading to the jaw or shoulder, nausea, sweating, general ill feeling;
- 肿胀，体重快，几乎没有小便；
- 严重的胃痛，恶心和呕吐；
- 使手指或脚趾变暗或紫色变色；
- 心跳非常缓慢，呼吸急促，感到头脑昏暗；
- 突然严重的背部疼痛，肌肉无力，麻木或手臂或腿部失去感觉；
- dangerously high blood pressure--severe headache, blurred vision, pounding in your neck or ears, nosebleed, anxiety, confusion, severe chest pain, shortness of breath, irregular heartbeats; or
- 胰腺炎- 上胃中的疼痛蔓延到您的背部，恶心和呕吐，快速心率。
这不是副作用的完整列表，其他可能发生。打电话给您的医生，征求有关副作用的医疗建议。您可以致电1-800-FDA-1088向FDA报告副作用。
Pregnancy & Breastfeeding
Can I takeUrokinase (Abbokinase)if I’m pregnant or breastfeeding?
In an emergency situation it may not be possible to tell your caregivers if you are pregnant or breast-feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medicine.
Interactions
我应该避免使用什么药物和食物Urokinase (Abbokinase)？
Ask your doctor before taking aspirin or ibuprofen(Motrin, Advil) shortly after you have received urokinase. These medications can increase your risk of bleeding.
避免活动可能会增加您出血或受伤的风险。在剃须或刷牙时，请格外小心，以防止出血。
剂量指南和提示
如何服用Urokinase (Abbokinase)？
UseUrokinase (Abbokinase)exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Urokinase is injected into a vein through an IV. A healthcare provider will give you this injection.
通常使用连续的输注泵在12小时内缓慢地给出尿激酶。
当您接受尿激酶时，将密切注意呼吸，血压，氧气水平和其他生命体征。
用尿激酶治疗后，您的医生可能会开出血液稀释剂或其他药物，以帮助防止未来的血块。Carefully follow all dosing instructions. These medications can make it easier for you to bleed, even from a minor injury.
因为您将在临床环境中收到尿激酶，所以您不太可能错过剂量。
过量的标志
如果我服用过量会发生什么Urokinase (Abbokinase)？
Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.