You should not use this medicine if you are allergic to estradiol or norethindrone, if you have had a hysterectomy, or if you have:
- unusual vaginal bleeding that has not been checked by a doctor;
- liver disease;
- a bleeding disorder;
- a history of heart attack, stroke, or blood clot; or
- a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina.
Do not use estradiol and norethindrone if you are pregnant.Tell your doctor right away if you become pregnant during treatment.
Using this medicine can increase your risk of blood clots, stroke, or heart attack.You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke.
Estradiol and norethindrone should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions.
Tell your doctor if you have ever had:
- heart disease;
- liver problems, or jaundice caused by pregnancy or taking hormones;
- hereditary angioedema (an immune system disorder);
- epilepsy or other seizure disorder;
- kidney disease;
- gallbladder disease;
- asthma;
- epilepsy or other seizure disorder;
- migraines;
- lupus;
- porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system);
- endometriosis or uterine fibroid tumors;
- a thyroid disorder; or
- high levels of calcium in your blood.
Using this medicine may increase your risk of cancer of the breast, uterus, or ovaries. Talk with your doctor about this risk.
Estradiol and norethindrone can slow breast milk production. Tell your doctor if you are breast-feeding.
