Andexxa (Coagulation Factor Xa)
Coagulation factor Xa is a protein that reverses the effects of certain anticoagulant medications that are used to treat or prevent blood clots. Reversing anticoagulant medicine is necessary if you have uncontrolled or life-threatening bleeding as a result of how that medicine works.
Coagulation factor Xa is used to treat uncontrolled bleeding in people who take the anticoagulants rivaroxaban (Xarelto) and apixaban (Eliquis).
Coagulation factor Xa was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, healthy volunteers responded to this medicine, but further studies are needed.
Coagulation factor Xa may also be used for purposes not listed in this medication guide.
uses
What isAndexxa (Coagulation Factor Xa)used for?
- Reversal of Anticoagulation
warnings
What is the most important information I should know aboutAndexxa (Coagulation Factor Xa)?
You should not be treated with coagulation factor Xa if you have had an allergic reaction to clotting factor medicine.
In an emergency, you may not be able to tell caregivers about your health conditions. Make sure any doctor caring for you afterward knows you received this medicine.
In an emergency, you may not be able to tell caregivers if you are pregnant or breast feeding. Make sure any doctor caring for your pregnancy or your baby knows you received this medicine.
Side Effects
What are the side effects ofAndexxa (Coagulation Factor Xa)?
Get emergency medical help if you havesigns of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
马上打电话给你的医生如果你有:
- pain or burning when you urinate;
- cough with mucus, chest pain, and shortness of breath;
- fever, chills; or
- continued bleeding after treatment.
Reversing the effects of anticoagulant medication may increase your risk of a blood clot, heart attack, stroke, or death. Get emergency medical help if you have any of these symptoms after being treated with coagulation factor Xa, especially if you have not started taking anticoagulant medication again:
- signs of a blood clot--sudden numbness or weakness, problems with vision or speech, swelling or redness in an arm or leg; or
- heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating.
Common side effects of coagulation factor Xa may include:
- lung problems;
- painful urination; or
- pain, swelling, burning, or irritation around the IV needle.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I takeAndexxa (Coagulation Factor Xa)if I’m pregnant or breastfeeding?
In an emergency, you may not be able to tell caregivers if you are pregnant or breast feeding. Make sure any doctor caring for your pregnancy or your baby knows you received this medicine.
Interactions
What drugs and food should I avoid while takingAndexxa (Coagulation Factor Xa)?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Dosage Guidelines & Tips
How to takeAndexxa (Coagulation Factor Xa)?
UseAndexxa (Coagulation Factor Xa)exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Coagulation factor Xa is given as an infusion into a vein. A healthcare provider will give you this injection.
This medicine must be given slowly, and the infusion can take at least 2 hours to complete.
Once your bleeding has been controlled, you may need to begin using anticoagulant medication again to prevent future blood clots.Follow your doctor's instructions very carefully.
Because you will receive coagulation factor Xa in a clinical setting, you are not likely to miss a dose.