Climara Pro(Transdermal)
Climara Pro(Transdermal)
Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body. Levonorgestrel is a form of progesterone, a female hormone important for regulating ovulation and menstruation.
Estradiol and levonorgestrel is a combination medicine used to treat menopause symptoms such as hot flashes, and to prevent osteoporosis (bone loss) in menopausal women.
Estradiol and levonorgestrel may also be used for purposes not listed in this medication guide.
uses
What isClimara Pro(Transdermal)used for?
- Postmenopausal Symptoms
- Prevention of Osteoporosis
warnings
What is the most important information I should know aboutClimara Pro(Transdermal)?
You should not use this medicine if you are allergic to estradiol or levonorgestrel, if you have had a hysterectomy, or if you have:
- unusual vaginal bleeding that has not been checked by a doctor;
- liver disease;
- a bleeding disorder;
- a history of heart attack, stroke, or blood clot; or
- a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina.
Do not use estradiol and levonorgestrel if you are pregnant.Tell your doctor right away if you become pregnant during treatment.
Using this medicine can increase your risk of blood clots, stroke, or heart attack.You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke.
Estradiol and levonorgestrel should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions.
Tell your doctor if you have ever had:
- heart disease;
- liver problems, or jaundice caused by pregnancy or taking hormones;
- hereditary angioedema (an immune system disorder);
- kidney disease;
- gallbladder disease;
- asthma;
- epilepsy or other seizure disorder;
- migraines;
- lupus;
- porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system);
- endometriosis or uterine fibroid tumors;
- a thyroid disorder; or
- high levels of calcium in your blood.
使用雌二醇可能增加患癌症的风险f the breast, uterus, or ovaries. Talk with your doctor about this risk.
Estradiol and levonorgestrel can slow breast milk production. Tell your doctor if you are breast-feeding.
Side Effects
What are the side effects ofClimara Pro(Transdermal)?
Get emergency medical help if you havesigns of an allergic reaction:hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
马上打电话给你的医生如果你有:
- heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
- signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
- signs of a blood clot--sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;
- memory problems, confusion, unusual behavior;
- unusual vaginal bleeding, pelvic pain;
- a lump in your breast; or
- high levels of calcium in your blood--nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, lack of energy.
Common side effects may include:
- nausea, vomiting, bloating, stomach cramps;
- fluid retention (swelling, rapid weight gain);
- headache;
- breast pain;
- redness or irritation where the patch was worn;
- thinning scalp hair; or
- vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I takeClimara Pro(Transdermal)if I’m pregnant or breastfeeding?
Do not use estradiol and levonorgestrel if you are pregnant.Tell your doctor right away if you become pregnant during treatment.
Estradiol and levonorgestrel can slow breast milk production. Tell your doctor if you are breast-feeding.
Interactions
What drugs and food should I avoid while takingClimara Pro(Transdermal)?
Avoid smoking. It can greatly increase your risk of blood clots, stroke, or heart attack while using estradiol and levonorgestrel.
Avoid exposing the patch to sunlight or tanning beds while you are wearing it on your skin.
Grapefruit may interact with estradiol and levonorgestrel and lead to unwanted side effects.Avoid the use of grapefruit products.
Dosage Guidelines & Tips
How to takeClimara Pro(Transdermal)?
UseClimara Pro(Transdermal)exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Apply the skin patch to clean, dry skin on your lower stomach. The patch should be worn around-the-clock for one week. Choose a different place on your lower stomach each time you apply a new patch. Avoid skin that is oily, irritated, or damaged.
Change your patch on the same day each week to stay on schedule.
Do not apply a skin patch to your breasts. Do not apply a patch where it might be rubbed off by tight clothing, such as under an elastic waistband.
If a patch falls off, try putting it back on to a different skin area, pressing the patch into place for 10 seconds. If the patch will not stick you may apply a new one.
If you need major surgery or will be on long-term bed rest,you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using estradiol and levonorgestrel.
Your doctor should check your progress on a regular basis to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis, and have regular mammograms while using estradiol and levonorgestrel.
Store patches at room temperature away from moisture and heat. Keep each patch in its pouch until you are ready to use it.
After removing a skin patch, fold it in half so it sticks together. Discard the folded patch in a place children and pets cannot get to.
Apply a skin patch as soon as you can, but skip the missed dose if it is almost time for your next dose.Do notapply two doses at one time.