You should not use valproic acid if you are allergic to it, or if you have:
- liver disease;
- 尿素周期障碍；或者
- a genetic mitochondrial (MYE-toe-KON-dree-al) disorder such as Alpers' disease or Alpers-Huttenlocher syndrome,especially in a child younger than 2 years old。
丙戊酸可能导致肝衰竭可能致命，尤其是在2岁以下的儿童和遗传线粒体疾病引起的肝脏问题的患者中。
Tell your doctor if you have ever had:
- 遗传线粒体疾病引起的肝问题；
- depression, mental illness, or suicidal thoughts or actions;
- 尿素周期障碍或婴儿死亡的家族病史；或者
- HIV or CMV (cytomegalovirus) infection.
Some young people have thoughts about suicide when first taking valproic acid. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.
怀孕期间使用丙戊酸可能会增加可能在怀孕初期出现严重出生缺陷的风险，甚至在您知道自己怀孕之前。怀孕期间使用这种药物也会影响孩子一生中的认知能力（推理，智力，解决问题）。但是，怀孕期间癫痫发作可能会伤害母亲和婴儿。
If you take valproic acid for seizures or manic episodes:防止这些疾病的好处可能超过该药物带来的任何风险。怀孕期间可能还有其他更安全使用的药物。没有医生的建议，请勿开始或停止服用丙戊酸。
Do not use valproic acid to prevent migraine headaches if you are pregnant or you could become pregnant.
如果您没有怀孕，请使用有效的避孕药在使用丙戊酸时预防妊娠。Tell your doctor if you start or stop using hormonal contraception that contains estrogen (birth control pills, injections, implants, skin patches, and vaginal rings). Estrogen can interact with valproic acid and make it less effective in preventing seizures.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
