Warfarin is an anticoagulant (blood thinner). Warfarin reduces the formation of blood clots.
Warfarin is used to treat or prevent blood clots in veins or arteries, which can reduce the risk of stroke, heart attack, or other serious conditions.
Warfarin may also be used for purposes not listed in this medication guide.
uses
What isWarfarin (Oral)(Oral)used for?
- Deep Vein Thrombosis -- Prophylaxis
- Myocardial Infarction
- Prevention of Thromboembolism in Atrial Fibrillation
- Pulmonary Embolism
- Thromboembolic Stroke Prophylaxis
- Heart Disease
- Pulmonary Impairment
- Cardiovascular Disease
- Myocardial Infarction -- Prophylaxis
- Deep Vein Thrombosis -- First Event
- Deep Vein Thrombosis -- Recurrent Event
- Pulmonary Embolism -- First Event
- Pulmonary Embolism -- Recurrent Event
- Prosthetic Heart Valves -- Tissue Valves
- Prosthetic Heart Valves -- Mechanical Valves
- Thrombotic/Thromboembolic Disorder
- Cerebral Thrombosis/Embolism
- Renal Vein Thrombosis
- 肺心脏或血管疾病
- Pulmonary Thromboembolism
- Thrombocythemia
- Thromboembolic Pulmonary Hypertension
warnings
What is the most important information I should know aboutWarfarin (Oral)(Oral)?
You should not take warfarin if you are allergic to it, or if:
- you have very high blood pressure;
- you recently had or will have surgery on your brain, spine, or eye;
- you undergo a spinal tap or spinal anesthesia (epidural); or
- you cannot take warfarin on time every day.
You also should not take warfarin if you are are prone to bleeding because of a medical condition, such as:
- a blood cell disorder (such as low red blood cells or low platelets);
- ulcers or bleeding in your stomach, intestines, lungs, or urinary tract;
- an aneurysm or bleeding in the brain; or
- an infection of the lining of your heart.
Do not take warfarin if you are pregnant, unless your doctor tells you to.Warfarin can cause birth defects, but preventing blood clots may outweigh any risks to the baby. If you are not pregnant, use effective birth control to prevent pregnancy while taking warfarin and for at least 1 month after your last dose.Tell your doctor right away if you become pregnant.
Warfarin can make you bleed more easily, especially if you have ever had:
- high blood pressure or serious heart disease;
- kidney disease;
- cancer or low blood cell counts;
- an accident or surgery;
- bleeding in your stomach or intestines;
- a stroke; or
- if you are 65 or older.
To make sure warfarin is safe for you, tell your doctor if you have ever had:
- diabetes;
- congestive heart failure;
- liver disease, kidney disease (or if you are on dialysis);
- a hereditary clotting deficiency; or
- low blood platelets after receiving heparin.
It is not known whether warfarin passes into breast milk. Watch for signs of bruising or bleeding in the baby if you take warfarin while you are breast-feeding a baby.
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Side Effects
What are the side effects ofWarfarin (Oral)(Oral)?
Get emergency medical help if you havesigns of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Warfarin increases your risk of bleeding, which can be severe or life-threatening.Call your doctor at once if you have any signs of bleeding such as:
- sudden headache, feeling very weak or dizzy;
- swelling, pain, unusual bruising;
- bleeding gums, nosebleeds;
- bleeding from wounds or needle injections that will not stop;
- heavy menstrual periods or abnormal vaginal bleeding;
- blood in your urine, bloody or tarry stools; or
- coughing up blood or vomit that looks like coffee grounds.
Clots formed by warfarin may block normal blood flow, which could lead to tissue death or amputation of the affected body part.Get medical help at once if you have:
- pain, swelling, hot or cold feeling, skin changes, or discoloration anywhere on your body; or
- sudden and severe leg or foot pain, foot ulcer, purple toes or fingers.
Bleeding is the most common side effect of warfarin.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I takeWarfarin (Oral)(Oral)if I’m pregnant or breastfeeding?
Do not take warfarin if you are pregnant, unless your doctor tells you to.Warfarin can cause birth defects, but preventing blood clots may outweigh any risks to the baby. If you are not pregnant, use effective birth control to prevent pregnancy while taking warfarin and for at least 1 month after your last dose.Tell your doctor right away if you become pregnant.
It is not known whether warfarin passes into breast milk. Watch for signs of bruising or bleeding in the baby if you take warfarin while you are breast-feeding a baby.
Interactions
What drugs and food should I avoid while takingWarfarin (Oral)(Oral)?
Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.You may still bleed more easily for several days after you stop taking warfarin.
Avoid making any changes in your diet without first talking to your doctor.Foods that are high in vitamin K (liver, leafy green vegetables, or vegetable oils) can make warfarin less effective. If these foods are part of your diet, eat a consistent amount on a weekly basis.
Grapefruit juice, cranberry juice, noni juice, and pomegranate juice may interact with warfarin and lead to unwanted side effects.Avoid the use of these juice products while taking warfarin.
Avoid drinking alcohol.
Ask your doctor before using any medicine for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others.These medicines may affect blood clotting and may also increase your risk of stomach bleeding.
Dosage Guidelines & Tips
How to takeWarfarin (Oral)(Oral)?
UseWarfarin (Oral)(Oral)exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take warfarin in larger or smaller amounts or for longer than your doctor tells you to.
Take warfarin at the same time every day, with or without food.Never take a double dose.
Warfarin can make it easier for you to bleed.Seek emergency help if you have any bleeding that will not stop.
您将需要频繁的“INR”或prothrombin time tests(to measure your blood-clotting time and determine your warfarin dose). You must remain under the care of a doctor while taking warfarin.
If you receive warfarin in a hospital, call or visit your doctor 3 to 7 days after you leave the hospital. Your INR will need to be tested at that time.Do not miss any follow-up appointments.
Tell your doctor if you are sick with diarrhea, fever, chills, or flu symptoms, or if your body weight changes.
You may need to stop taking warfarin 5 to 7 days before having any surgery, dental work, or a medical procedure. Call your doctor for instructions.
Wear a medical alert tag or carry an ID card stating that you take warfarin. Any medical care provider who treats you should know that you are taking this medicine.
Store at room temperature away from heat, moisture, and light.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose.Do nottake extra medicine to make up the missed dose.
Overdose Signs
What happens if I overdose onWarfarin (Oral)(Oral)?
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