Kadcyla (Ado-Trastuzumab Emtansine)
Ado-trastuzumab emtansine is used to treat a HER2-positive breast cancer. This medicine is used both for early breast cancer and for breast cancer that has spread to other parts of the body (metastatic).
Ado-trastuzumab emtansine is usually given after other treatments have failed.
Kadcyla (ado-trastuzumab) should not be used in place of Herceptin (trastuzumab).
Ado-trastuzumab emtansine may also be used for purposes not listed in this medication guide.
uses
What isKadcyla (Ado-Trastuzumab Emtansine)used for?
- Breast Cancer
- Breast Cancer -- Male
- Neoplasia -- Estrogen Dependent
warnings
What is the most important information I should know aboutKadcyla (Ado-Trastuzumab Emtansine)?
Tell your doctor if you have ever had:
- heart problems;
- liver disease (especially hepatitis B or C);
- bleeding or blood clotting disorder such as hemophilia; or
- asthma, chronic obstructive pulmonary disease (COPD), sleep apnea, or other breathing disorder.
You may need to have a negative pregnancy test before starting this treatment.
Ado-trastuzumab emtansine can harm an unborn babyif the mother or the father is using this medicine.
- If you are a woman,do not use ado-trastuzumab emtansine if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 7 months after your last dose.
- If you are a man,use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 4 months after your last dose.
- Tell your doctor right away if a pregnancy occurs while either the mother or the father is using ado-trastuzumab emtansine.
Do not breastfeed while using this medicine,and for at least 7 months after your last dose.
Side Effects
What are the side effects ofKadcyla (Ado-Trastuzumab Emtansine)?
Get emergency medical help if you havesigns of an allergic reaction:hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some side effects may occur during the injection. Tell your caregiver right away if you feel cold, light-headed, feverish or sweaty, or have chest tightness, rapid heartbeats, or trouble breathing.
打电话给你的医生啊nce if you have:
- easy bruising, unusual bleeding, purple or red spots under your skin;
- coughing up blood or vomit that looks like coffee grounds;
- bloody or tarry stools;
- chest pain, wheezing, dry cough;
- unusual tiredness, feeling light-headed;
- pale skin, cold hands and feet;
- numbness, tingling, or burning pain in your hands or feet;
- sudden numbness or weakness (especially on one side of the body), severe headache, slurred speech, balance problems;
- heart problems--swelling in your lower legs, rapid weight gain, feeling short of breath, cough, fast or pounding heartbeat, dizziness, feeling like you might pass out;
- liver problems--loss of appetite, stomach pain (upper right side), dark urine, jaundice (yellowing of the skin or eyes); or
- signs of tumor cell breakdown--confusion, weakness, muscle cramps, nausea, vomiting, fast or slow heart rate, decreased urination, tingling in your hands and feet or around your mouth.
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects may include:
- easy bruising or bleeding (especially nosebleeds);
- nausea, constipation;
- joint or muscle pain;
- headache; or
- feeling tired.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Pregnancy & Breastfeeding
Can I takeKadcyla (Ado-Trastuzumab Emtansine)if I’m pregnant or breastfeeding?
You may need to have a negative pregnancy test before starting this treatment.
Do not breastfeed while using this medicine,and for at least 7 months after your last dose.
Interactions
What drugs and food should I avoid while takingKadcyla (Ado-Trastuzumab Emtansine)?
Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.
Dosage Guidelines & Tips
How to takeKadcyla (Ado-Trastuzumab Emtansine)?
UseKadcyla (Ado-Trastuzumab Emtansine)exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Ado-trastuzumab emtansine is given as an infusion into a vein. A healthcare provider will give you this injection.
This medicine must be given slowly, and the infusion can take 30 to 90 minutes to complete.
Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when ado-trastuzumab emtansine is injected.
ev Ado-trastuzumab emtansine通常是给一次ery 3 weeks. Your doctor will determine how long to treat you.
You may need frequent medical tests to be sure this medicine is not causing harmful effects. Your cancer treatments may be delayed based on the results.
Call your doctor for instructions if you miss an appointment for your ado-trastuzumab emtansine injection.
Overdose Signs
What happens if I overdose onKadcyla (Ado-Trastuzumab Emtansine)?
Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.